Multiphysics Modeling and Simulation of Nanoscale Cantilever Array Sensor for the Detection of HIV Antigens

Sowmya Selvaraj, Steffie Mano, PonJanani Sugumaran, Jaisree Meenaa Pria Jayaraman, Meenakshi Sundaram Nachiappan

Abstract


Acquired Immuno Deficiency Syndrome (AIDS) is a major immune disease that weakens the ability of the human defense system to protect against infections and certain types of cancer. The causative organism for the disease, Human Immuno Deficiency Virus (HIV) has targeted the global public claiming the lives of about 25 million over the past three decades. This demonstrates the need for an early and accurate detection of HIV. The HIV viral core made of p24 protein, when detected by conventional antigen test could measure only above 10 pg/ml after 10 to 14 days of infection. Eliminating this inefficacy, cantilevers stand out as an alternate platform to detect the virus in a shorter time. The influence of the cantilever dimensions on its sensitivity enables quicker detectability of the virus. Hence, in this paper we propose to design a nanoscale cantilever array sensor for p24 detection using COMSOL Multiphysics 4.3b®. The optimization of the cantilever structure with different materials is also performed. The modeled cantilever will thus be highly sensitive to HIV in comparison to the laboratory p24 antigen test method and detect less than femto gram/ml level of antigen.

Keywords


Cantilever, Antigen, Antibody, Acquired Immuno Deficiency Syndrome, Human Immunodeficiency Virus, COMSOL Multiphysics.

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